March 1985

Fatal Gastroenteritis Associated With Coronaviruslike Particles

Author Affiliations

From the Departments of Pediatrics (Dr Rettig) and Pathology (Dr Altshuler), College of Medicine, University of Oklahoma Health Sciences Center; and Oklahoma Children's Memorial Hospital (Drs Rettig and Altshuler), Oklahoma City.

Am J Dis Child. 1985;139(3):245-248. doi:10.1001/archpedi.1985.02140050039017

• The role of human enteric coronaviruses in infantile gastroenteritis is controversial. We detected coronavirus-like particles in the intestinal contents and within the epithelial cells of the ileum in a 15-month-old infant who had postmortem evidence of severe enteritis. Ultrastructural findings consistent with in vivo coronavirus replication in the human small intestine support a causative role for this agent in gastroenteritis.

(AJDC 1985;139:245-248)