Sir.—Association between hepatitis B surface antigen (HBsAg) and hepatocellular carcinoma (HCC) has been strongly suggested by Szmuness,1 and integrated hepatitis B virus DNA (HBV-DNA) has been demonstrated in human HCC cell lines.2 It has also been strongly suggested that HCC patients acquire hepatitis B virus from their mothers during the perinatal period in populations with a high HBsAg prevalence. To our knowledge, this association has been reported only in adults, more in men than in women.
Patient Report.—A 10-year-old Turkish boy had HCC in whom HBsAg was present but in whom anti–HBs remained negative. He was seen in this hospital on Sept 21, 1984, because of a protuberant abdomen, lassitude for 1½ months' duration, and recent jaundice. He was underdeveloped, cachectic (weight, 24 kg; height, 125 cm; both values less than third percentile), and jaundiced. The liver was markedly enlarged with several very hard masses. The spleen
KOÇAK N, ÖZSOYLU Ş, SARIALIOGLU F, GOKSU N. Association Between Hepatitis B Surface Antigen and Hepatocellular Carcinoma. Am J Dis Child. 1985;139(9):858. doi:10.1001/archpedi.1985.02140110012005