September 1985

Hepatitis B Virus and Schönlein-Henoch Purpura

Author Affiliations

Faculty of Medicine Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812, Japan

Am J Dis Child. 1985;139(9):861. doi:10.1001/archpedi.1985.02140110015013

Sir.—We read with interest the report by Maggiore et al.1 They suggested the causal relationship between hepatitis type B virus (HBV) infection and Schönlein-Henoch (S-H) purpura. We had also studied hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (HBsAb) on 35 Japanese children with S-H purpura (age range, 2 to 14 years) by using radioimmunoassay. Of these 35 children studied, 23 (66%) were found to have renal involvements. One 7-year-old boy showed mild liver dysfunction with positive tests for both HBsAg and hepatitis Be antigen (HBeAg). However, he was found to have no anti–HB-core IgM antibody, but since the HBsAg and HBeAg had been positive for eight months, he was considered to be an HBs carrier. Therefore, it is unlikely to see any relationship between HBV and S-H purpura in this case. Nagy et al2 reported two cases of positive tests for HBsAg in 11

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