[Skip to Content]
[Skip to Content Landing]
September 1985

Increased Urinary Excretion of Renal Glucosaminidase in Hypercalciuria

Author Affiliations

From the Departments of Pediatrics, University of Tennessee Center for the Health Sciences and the LeBonheur Children's Medical Center, Memphis (Dr Stapleton and Ms Miller), and University of Wisconsin Center for the Health Sciences, Madison (Drs Chesney and Behrmann).

Am J Dis Child. 1985;139(9):950-952. doi:10.1001/archpedi.1985.02140110104041

• Urinary excretion of N-acetyl-β-glucosaminidase (NAG), a lysosomal enzyme, was examined In 33 children with hypercalciuria. Urinary NAG excretion In 13 healthy children was 5.84±9.35 nmole/hr/mg of creatinine (NAG/Cr) (mean±SD) compared with 35.61±42.04 nmole/hr/mg of creatinine in 23 children with renal hypercalciuria, and 28.99 ±13.69 nmole/hr/mg of creatinine In ten children with absorptive hypercalciuria. In children with renal hypercalciuria, NAG/Cr excretion was not statistically different between children with either urolithiasis or hematuria without calculi. In six children with renal hypercalciuria, no significant change in NAG/Cr excretion occurred after a mean duration of 25 weeks of hydrochlorothiazide therapy although urinary calcium to creatinine ratios (UCa/Cr) decreased from 0.24±0.11 to 0.16±0.11. We conclude that increased urinary calcium excretion produces renal tubular injury and that the renal injury may not be reversed by short-term alterations in urinary calcium excretion.

(AJDC 1985;139:950-952)