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Article
October 1985

Complications Involving Augmentin

Author Affiliations

Department of Pediatrics University of Kentucky Lexington, KY 40536

Am J Dis Child. 1985;139(10):962. doi:10.1001/archpedi.1985.02140120008002
Abstract

Sir.—I would like to report my experience with Augmentin, released by Beecham Laboratories, Bristol, Tenn, in 1984. Augmentin is an oral antibacterial consisting of amoxicillin trihydrate and clavulanic acid, a β-lactamase inhibitor. This antibiotic has broad-spectrum activity effective for many gram-positive, gram-negative, and β-lactamase–producing organisms.1 It has been efficacious in treating lower respiratory tract infections, otitis media, sinusitis, urinary tract infections, and skin and skin structure infections, with success reported in 90% of more than 1,500 patients (data on file, Medical Department, Beecham Laboratories).

Results for 1,529 treated patients (499 children and 1,030 adults) indicate few side effects such as diarrhea/loose stools (9%), nausea (3%), rashes and urticaria (3%), vomiting (1%), and vaginitis (1%) (data on file, Medical Department, Beecham Laboratories). Less than 3% of individuals receiving Augmentin had therapy terminated for drug-related side effects. However, 70% of all patients I have treated with Augmentin for otitis

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