December 1985

Infants Born to Women With Chlamydia trachomatis Infection-Reply

Author Affiliations

Department of Pediatrics Arizona Health Sciences Center 1501 N Campbell Ave Tucson, AZ 85724
Division of Sexually Transmitted Diseases Centers for Disease Control 1600 Clifton Rd Atlanta, GA 30333

Am J Dis Child. 1985;139(12):1177-1178. doi:10.1001/archpedi.1985.02140140011003

In Reply.—We appreciate McMillan and Weiner's concerns about misclassification of"exposed" and "unexposed" infants and the possible consequences for the results of our study.1 We would like to take the opportunity provided by their letter to comment further on these issues, since the effects of potential misclassification may not be widely appreciated.

McMillan and Weiner's first point concerns the possibility that infants born to women who received antibiotics that are effective against C trachomatis were misclassified as exposed to C trachomatis. As noted in our discussion of the results, we did not have information on the use of antibiotic therapies during the pregnancies of this group of women. However, misclassification of infants who were actually unexposed (because their mothers received antibiotics effective against C trachomatis) would exert a conservative bias on the results—that is, the associations we reported between exposure to C trachomatis and rates of pneumonitis and recurrent

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