January 1986

Preliminary Observation of Impaired Water Excretion in Treated Status Asthmaticus

Author Affiliations

From the Department of Pediatrics, Children's Memorial Hospital, Northwestern University School of Medicine, Chicago.

Am J Dis Child. 1986;140(1):59-61. doi:10.1001/archpedi.1986.02140150061036

• Patients in status asthmaticus often have elevated plasma antidiuretic hormone levels. To determine if children in status asthmaticus have impaired water excretion and an increased risk of developing significant hyponatremia when given a fluid challenge, five consecutive patients who showed moderate asthmatic symptoms after taking two doses of epinephrine hydrochloride were given a fluid challenge (20 mL/kg of 5% dextrose in 0.2% normal saline solution given intravenously over 30 minutes followed by maintenance fluids [1,500 mL/sq m/24 hr] for 50 minutes). Urine was collected at 20-minute intervals for measurement of free-water clearance and percent water-load excretion in 80 minutes. This protocol was repeated 24 to 48 hours later, after clinical improvement. None of the patients was hyponatremic during status asthmaticus before water loading. However,