February 1986

Restoration of Suppressor T-Cell Functions in Children With AIDS Following Intravenous Gamma Globulin Treatment

Author Affiliations

From the Departments of Pediatrics (Division of Allergy and Immunology) and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY.

Am J Dis Child. 1986;140(2):143-146. doi:10.1001/archpedi.1986.02140160061033

• Suppressor T-cell function was analyzed in seven children with acquired autoimmunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). Four of the patients had markedly increased serum IgG levels. All patients had elevated percentages and absolute numbers of peripheral blood T8 cells. In vitro concanavalin A generation of suppressor cells for T-cell mitogenic responses and suppression of pokeweed mitogendriven immunoglobulin secretion were diminished in all patients. After intravenous treatment with gamma globulin, four patients regained in vitro suppression of pokeweed mitogen-driven gamma globulin secretion. Treatment with intravenous gamma globulin also modified in vitro suppressor T-cell functions in children with AIDS or ARC.

(AJDC 1986;140:143-146)