• Five young adults with malignant neoplasms developed symptoms of narcotic withdrawal six to 48 hours after the abrupt discontinuation of narcotic therapy that had been administered for six to 21 days. The symptoms, which included agitation, irritability, muscular jerks, abdominal pain, diarrhea, burning sensations, "gooseflesh," and itching, rapidly resolved when narcotic therapy was reinstituted. Four patients were then successfully weaned from opiates without recurrence of their withdrawal symptoms; the fifth patient continues to receive methadone hydrochloride treatment for continuing pain.
Miser AW, Chayt KJ, Sandlund JT, Cohen PS, Dothage JA, Miser JS. Narcotic Withdrawal Syndrome in Young Adults After the Therapeutic Use of Opiates. Am J Dis Child. 1986;140(6):603–604. doi:10.1001/archpedi.1986.02140200113039