[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 23.23.54.109. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
August 1986

Familial Sexual Precocity

Author Affiliations

Department of Pediatrics East Virginia Medical School 800 W Olney Rd PO Box 1980 Norfolk, VA 23507

Am J Dis Child. 1986;140(8):741-742. doi:10.1001/archpedi.1986.02140220023017
Abstract

Sir.—Dr Ruvalcaba's letter concerning the rarity of familial isosexual precocity in females intrigued us, since anecdotally our experience was different.1 We then reviewed the charts of 58 girls in whom isosexual precocious puberty had been diagnosed. They were all seen in our endocrine clinic over the past six years. Three girls (5.2%) had family histories indicating that other family members had also experienced sexual precocity.

Patient Reports.—Patient 1.—A girl aged 7 years 11 months had onset of breast development at age 6 years and pubic hair development at 7½ years of age. Her height age was 11½ years. Breast and pubic hair development were each at Tanner stage III. Her bone age was 11½ years. Laboratory values included: follicle-stimulating hormone (FSH), 3.2 mIU/mL (IU/L); luteinizing hormone (LH), 4.7 mIU/mL (IU/L) (prepubertal normal levels for each, 5 mIU/mL [IU/L]); and estradiol, 58 pg/mL (213 pmol/L) (prepubertal normal,

First Page Preview View Large
First page PDF preview
First page PDF preview
×