January 1987

Treatment of Idiopathic Chronic Neutropenia With High-Dose Intravenous Immunoglobulin

Author Affiliations

Central Municipal Hospital for Infectious Diseases "László" PO Box 29 H-1450, Budapest, Hungary

Am J Dis Child. 1987;141(1):12-13. doi:10.1001/archpedi.1987.04460010012006

Sir.—It was a great pleasure to read the report by Ducos and colleagues,1 especially since we also obtained beneficial effects by treating a patient with idiopathic chronic neutropenia with high-dose intravenous γ-globulin.

Patient Report.—We admitted the subject, a 6-month-old female infant, for the first time on Dec 7, 1984. She had had chronic diarrhea, vomiting, and growth failure for six weeks. At the time of admission, she had prolonged bleeding time, neutrophil granulopenia, and lack of prothrombin. The patient became gradually atrophic, and a serious septic condition developed. We diagnosed mastoiditis as the cause. We performed a mastoidectomy on Dec 28. After the operation, the granulocyte count and the red blood cell count continually decreased, and she was given several transfusions. The bone marrow examination revealed normal granulopoiesis. Beginning in March 1985, her condition improved and her weight increased. The red blood cell count and the prothrombin

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