Denouement and Discussion
Darier's sign is present in patients with urticaria pigmentosa (Fig 2) and consists of the formation of urticaria after minimal rubbing. In the systemic form of this condition, the liver, spleen, bone, bone marrow, and lymph nodes may be affected.
The nephritis of Schönlein-Henoch syndrome (Fig 3, top and bottorn) is manifested by microscopic hematuria, episodic gross hematuria, proteinuria, and the nephrotic syndrome. Renal findings are usually present within a month of the onset of the syndrome, and in most instances the syndrome, and in most instances the syndrome is self-limiting.
In patients with varicella-zoster virus or other herpesvirus (Fig 1), a Tzanck smear of the lesions demonstrates multinucleated giant cells that contain intranuclear inclusions.
Moyer FG, Feingold M. Picture of the Month. Am J Dis Child. 1987;141(2):215-216. doi:10.1001/archpedi.1987.04460020105040