March 1987

Joint and Pulmonary Changes in Diabetes-Reply

Author Affiliations

Department of Pediatric Endocrinology
Department of Critical Care Medicine
Department of Pediatric Rheumatology Childrens Hospital of Orange County PO Box 5700 Orange, CA 92268
Division of Dermatology UCLA School of Medicine

Am J Dis Child. 1987;141(3):245. doi:10.1001/archpedi.1987.04460030022014

In Reply.—We appreciate the additional information offered by Dr Madácsy. His findings1 were consistent with those of our studies.2 As he suggested, we did analyze our data to compare the vital capacities between diabetic patients with LJM and those without LJM, but we found no significant difference between the two groups by Χ2, multiway table, or linear regression analysis. In a previous study of three diabetic patients with severe LJM, we performed detailed pulmonary function tests, including spirometry, body plethysmography, nitrogen washout curves, and arterial blood gas measurements.3 In these patients, we demonstrated decreased vital capacities, decreased total lung capacities, an abnormal slope of phase III of the nitrogen washout curve, and abnormal oxygenation; however, the patients had normal airway resistance and normal PEF50 and, therefore, had no evidence of obstructive airway disease. To examine a large number of children (N = 375) at a

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