March 1987

Thymic Hypoplasia Associated With Isotretinoin Embryopathy

Author Affiliations

From the Division of Neonatology, Department of Pediatrics (Drs Cohen and Nathenson), the Division of Allergy and Immunology (Dr Rubinstein), and the Department of Pathology (Dr Li), Albert Einstein College of Medicine, North Central Bronx Hospital, and Montefiore Medical Center. Dr Cohen is now with Newark (NJ) Beth Israel Medical Center.

Am J Dis Child. 1987;141(3):263-266. doi:10.1001/archpedi.1987.04460030041020

• A newborn had isotretinoin embryopathy, including thymic hypoplasia. Evaluation of her immune functions demonstrated progressive attrition of T cells over the nine weeks until her death due to pneumonia. These studies strongly suggest an insult by isotretinoin to the immune system. Immune abnormalities may predispose infants with isotretinoin embryopathy to infection and contribute to their high mortality.

(AJDC 1987;141:263-266)