June 1987

Hepatocarcinoma in a Child With the Alagille Syndrome

Author Affiliations

From the Departments of Pediatrics (Drs Kaufman and Vanderhoof), Surgery (Drs Wood and Shaw), and Pathology (Dr Markin), University of Nebraska College of Medicine, Omaha; and the Department of Surgery, University of Milan (Italy) (Dr Gridelli).

Am J Dis Child. 1987;141(6):698-700. doi:10.1001/archpedi.1987.04460060114050

• A child with the Alagille syndrome of intrahepatic bile duct paucity developed hepatocarcinoma. Disabling cirrhosis had rendered this child a suitable candidate for transplantation before the discovery of carcinoma. However, the extension of the tumor outside the liver precluded the performance of this potentially life-saving operation. Serial monitoring of the serum μ-fetoprotein concentration may be of value in the early identification of tumors in pediatric candidates for transplantation.

(AJDC 1987;141:698-700)