Sir.—The evaluation of prepubertal girls with virilization entails detailed biochemical study. Although the androgens causing the virilization may be identified by analyzing urine and plasma, the source of the increased androgen production frequently remains obscure. Herein we describe two virilized prepubertal girls who had lipoid cell tumors of the ovary.
These patients emphasize the necessity of abdominal imaging to appropriately establish the source of abnormal steroid production.
Virilization of prepubertal girls that is not due to congenital virilizing adrenal hyperplasia is usually caused by androgens arising from an abnormality of the adrenal glands or ovaries. While analysis of urine and plasma may identify the androgen(s) causing the virilization, the anatomic origin of the abnormality frequently cannot be specifically localized by biochemical methods or physical examination. Therefore, abdominal imaging techniques may be necessary to localize and characterize the anatomic abnormality. Two prepubertal girls who experienced virilization caused by lipoid cell
Cleveland RH, Kushner DC, Russell WE, Herman TE, Kim SH, Crawford J. Lipoid Cell Tumor of the Ovary: A Cause of Virilization in Girls. Am J Dis Child. 1987;141(7):716-718. doi:10.1001/archpedi.1987.04460070018005