July 1987

Sweet's Syndrome and Chronic Recurrent Multifocal Osteomyelitis

Author Affiliations

206 Steeplechase E Irving, TX 75062

Am J Dis Child. 1987;141(7):721. doi:10.1001/archpedi.1987.04460070023009

Sir.—The patient report by Edwards et al1 in the August 1986 issue of AJDC describing a patient with Sweet's syndrome, with an associated sterile osteomyelitis, "an association that, to our knowledge, has never been previously reported," is very similar to the entity described by Giedeon et al2 and recently by Weiner et al3 as chronic recurrent multifocal osteomyelitis (CRMO).

In contrast to Sweet's syndrome, classically a disease afflicting older women, CRMO is common in children and, as in the patient described by Edwards et al, is characterized by multiple areas compatible with osteomyelitis, pustulosis of the skin, response to steroid therapy, lack of response to antibiotic therapy, and the absence of a demonstrable causative agent.

The authors' statement that CRMO does not improve with steroid therapy is contradicted by five articles cited by Weiner et al.3 The indication that cutaneous lesions are rare in CRMO

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