October 1987

Safe Immunization of Allergic Children Against Measles, Mumps, and Rubella

Author Affiliations

From the Children's Hospital (Drs JuntunenBackman, Peltola, and Backman) and the DePartment of Allergic Diseases (Drs JuntunenBackman, Backman, and Salo), University of Helsinki, and the National Public Health Institute, Helsinki (Dr Peltola).

Am J Dis Child. 1987;141(10):1103-1105. doi:10.1001/archpedi.1987.04460100081032

• A series of 135 subjects (134 children and one adult) with documented or suspected systemic allergy were pricktested before a measles, mumps, and rubella (MMR) vaccination. Atopic eczema was documented in 68, asthma in 47, and cow's-milk allergy in 11 examinees; eight children were evaluated because of severe systemic reactions following diphtheria-pertussis-tetanus, measles, or inactivated polio (Salk) vaccinations. In one child, there was only a suspicion of general allergy. The undiluted MMR prick test gave negative reactions in 126 cases (93%). The highest rate of nonreactivity was observed in those with atopic eczema (96%) and in children with asthma (91%) or cow's-milk allergy (82%). All examinees with systemic reactions after other vaccinations also had negative prick-test reactions. A total of 122 (95%) of the 129 examinees were eventually vaccinated with MMR. No untoward reactions developed, except mild generalized urticaria or fever in two vaccinees. We conclude that at least 95% of children with common forms of systemic allergy can be vaccinated safely with MMR and, In general, that allergic diseases should not interfere with execution of the vaccination programs.

(AJDC 1987;141:1103-1105)