November 1987

Antenatal Hypoxia and IQ Values-Reply

Author Affiliations

Department of Pediatrics Medical College of Georgia Augusta, GA 30912-3500

Am J Dis Child. 1987;141(11):1150-1151. doi:10.1001/archpedi.1987.04460110020008

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Sir.—We are concerned about the analytic and statistical approach taken by Naeye and Peters in their study investigating the influence of antenatal hypoxia on IQ values. In the first part of their study, the authors examined the influence of acute and chronic hypoxia on IQ values in children with and without neurologic abnormalities. After accounting for the influences of sociohereditary, demographic, and fetal growth factors, a stepwise multiple regression analysis was used to determine the effect of each hypoxic factor. The first problem with this study is that their Tables 2 through 6 do not accurately reflect this analysis and fail to provide us with enough meaningful information to evaluate the results. In these tables the authors have recorded unstandardized β coefficients and P values. First, we are not told whether the P values correspond to the total regression model after the specific variable was added or to the

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