November 1987

A New Hypospadias–Mental Retardation Syndrome in Three Brothers

Author Affiliations

From the Medical Research Council Unit for Inherited Skeletal Disorders, Department of Human Genetics and Medicine, University of Cape Town Medical School and Groote Schuur Hospital, Republic of South Africa.

Am J Dis Child. 1987;141(11):1168-1169. doi:10.1001/archpedi.1987.04460110038017

• Three brothers had a syndrome of hypospadias and mental retardation in association with microcephaly, craniofacial dysmorphism, joint laxity, and beaked nails. No other family members were affected, and this previously undelineated condition appears to be inherited in either an autosomal recessive or X-linked recessive mode.

(AJDC 1987;141:1168-1169)