[Skip to Content]
[Skip to Content Landing]
December 1987

Premature Thelarche in Puerto Ric[ill]-Reply

Author Affiliations

Center for Environmental Health Centers for Disease Control Public Health Service US Department of Health and Human Services Atlanta, GA 30333

Am J Dis Child. 1987;141(12):1251. doi:10.1001/archpedi.1987.04460120012007

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


In Reply.—The issue of a dose-response relationship, brought up by Ms Montague-Brown, is important. Finding a dose-response relationship is strong support that an association is not due to chance. Our data include information about the subjects' ages when various food items were introduced in the diet. We do not, however, have detailed information about the frequency of consumption and amounts of foods consumed over time. Even if such data were available, it would still not be appropriate to combine various exposures into one variable, as suggeted by Ms MontagueBrown, because we would not know how much weight to assign to each factor.

First Page Preview View Large
First page PDF preview
First page PDF preview