Sir.—Marion et al1 have pointed out (1) facial dysmorphism in embryopathy due to human immunodeficiency virus (HIV) and (2) a defect in the immune T-cell system in isotretinoin embryopathy.2 My colleagues and I too have observed the presence of facial dysmorphism in acquired immunodeficiency syndrome (AIDS) embryopathy and have hypothesized a similar defect embryopathy caused by hypervitaminosis A.3 My colleagues and I believe that AIDS and the isotretinoin embryopathies can be included in a more comprehensive syndromic picture, ie, in neurocristopathies that may or may not be linked to chromosomal anomalies (eg, trisomy 13, mosaic monosomy C, fetal alcohol syndrome, Aicardi's syndrome, and de Lange's syndrome),3 with defects in the T-cell system and facial dysmorphism.
There are common characteristics (eg, intrauterine birth defect, microencephalia, prominent forehead, hypertelorism, epicanthal folds, antimongoloid slant of the palpebral fissures, anomalies of the auricle, broad-based nose, saddle nose, micrognathia, and
CALVANI M. HIV Embryopathy and Neurocristopathies. Am J Dis Child. 1988;142(1):10. doi:10.1001/archpedi.1988.02150010016003