• In 32 children with pauciarticular juvenile rheumatoid arthritis, we studied residual muscle atrophy and leg length discrepancy after the arthritis had entered remission. Children under the age of 3 years at disease onset had significantly more muscle atrophy and bone overgrowth than children whose disease began after the age of 3 years. These residua have cosmetic and functional significance, and new methods of treatment will be necessary to prevent or reverse the sequelae in a form of arthritis previously thought to have a benign outcome.
Vostrejs M, Hollister JR. Muscle Atrophy and Leg Length Discrepancies in Pauciarticular Juvenile Rheumatoid Arthritis. Am J Dis Child. 1988;142(3):343-345. doi:10.1001/archpedi.1988.02150030117036