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July 1988

Luteinizing Hormone Releasing Hormone and Human Behavior

Author Affiliations

Department of Pediatrics Brooke Army Medical Center Fort Sam Houston, TX 78234-6200

Am J Dis Child. 1988;142(7):699-700. doi:10.1001/archpedi.1988.02150070013005

Sir.—The effects of luteinizing hormone releasing hormone (LHRH) on the sexual behavior of rats are well documented.1-3 The data on adult humans are limited, and the data on children are nonexistent. We report the sexual and aggressive responses of children and adults after administration of LHRH.

Patient Reports.—Patients and Methods.—Three males and two females, 11, 15, 18, 26, and 28 years old, suffering from Kallman's syndrome (one patient), delayed puberty (one patient), prepuberty (one patient), and infertility of undetermined cause (two patients) were studied. None manifested pathologic personality problems. No organic or intracranial lesion was detected. Each subject received intramuscular injections of 100 μg/m2 of LHRH daily as a diagnostic agent for three consecutive days. All subjects were informed of the use of LHRH as a diagnostic agent; we did not discuss whether LHRH affects thoughts or behavior. A Rorschach Test and Thematic Apperception Test

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