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August 1988

The Natural History of Acquired Cytomegalovirus Infection Among Children in Group Day Care

Author Affiliations

From the Divisions of Ambulatory Pediatrics (Dr Murph) and Pediatric Neurology (Dr Bale), Departments of Pediatrics and Neurology, University of Iowa College of Medicine, Iowa City.

Am J Dis Child. 1988;142(8):843-846. doi:10.1001/archpedi.1988.02150080049020

• We studied the natural history of cytomegalovirus (CMV) excretion among 79 children in a single day-care center over a 2½-year period. During the study interval, 28 children (35%) excreted CMV in their urine, or saliva, or both. The CMV acquisition rate among children who were initially culture negative was 12.6% per year. In such children, CMV excretion began 11 to 59 months after entry into day care. The duration of CMV excretion varied from 3.0 to 28.4 months, with a mean of 13.0 ±9.1 months for urine and 7.0±2.7 months for saliva. The quantity of CMV in saliva or urine was highest during the first three months of excretion, as high as 105 50% tissue culture infectious dose per milliliter. Children excreting CMV entered day care at a younger age (mean, 5.3±8.5 months for excretors vs 12.7±14.8 months for nonexcretors) and spent more hours in day care per week than the nonexcretors (mean, 41.8±9.0 h/wk for excretors vs 36.1±10.9 h/wk for nonexcretors).

(AJDC 1988;142:843-846).