November 1988

Chronic Osteomyelitislike Disease With Negative Bacterial Cultures

Author Affiliations

From the Children's Hospital (Drs Pelkonen, Ryöppy, Jääskeläinen, and Rapola) and the Departments of Infectious Diseases (Dr Repo) and Medical Genetics (Dr Kaitila), University of Helsinki.

Am J Dis Child. 1988;142(11):1167-1173. doi:10.1001/archpedi.1988.02150110045017

• During a seven-year period we observed 14 children who had chronic osteomyelitislike disease. The bacterial cultures from the bone lesions were negative. In eight patients the findings were compatible with chronic recurrent multifocal osteomyelitis (CRMO), in four the findings were compatible with chronic sclerosing osteomyelitis of Garré, and two had osteomyelitis of the clavicle. In patients with CRMO, lymphocyte subpopulations, the responses to mitogens, and the chemotactic and chemokinetic responses showed no consistent abnormalities. After a mean followup of 4.5 years (range, one to ten years), all four patients with osteomyelitis of Garré were symptomatic, and two had complications. Only two of the eight patients with CRMO had active disease. The course had been complicated by growth disturbances in one patient and by thoracic outlet syndrome in another. Wegener's granulomatosis later developed in a patient with CRMO.

(AJDC 1988;142:1167-1173)