• Tumor necrosis factor α and interleukin 1β concentrations were measured in synovial fluid of 24 infants and children with diagnoses of suppurative arthritis (n = 16) and other kinds of arthritis (n = 8). Large concentrations of tumor necrosis factor α (range, 100 to 85 000 pg/mL) were found in 12(75%) of 16 patients with bacterial infection and in none of the patients with noninfectious origins. Large concentrations of interleukin 1β (200 pg/mL) were found in 15(94%) of 16 patients with bacterial infection and in none of the other patients. In the latter group, small concentrations of interleukin 1 (range, 40 to 120 pg/mL) were present in 5 (63%) of 8 patients. Serum samples obtained simultaneously were negative for both cytokines. Tumor necrosis factor α and interleukin 1β concentrations correlated significantly and with leukocyte counts in synovial fluid. We conclude that large concentrations of tumor necrosis factor α and interleukin 1β are produced locally in patients with suppurative arthritis and they may be potentially useful in differentiating this condition from other kinds of arthritis.
Llorens XS, Mustafa MM, Ramilo O, Fink C, Beutler B, Nelson JD. Tumor Necrosis Factor α and Interleukin 1β in Synovial Fluid of Infants and Children With Suppurative Arthritis. Am J Dis Child. 1990;144(3):353-356. doi:10.1001/archpedi.1990.02150270103035