October 1990

Transient Myeloproliferative Disorder of the Down Type in the Normal Newborn

Author Affiliations

From the Department of Pediatrics (Drs Ridgway, Benda, Magenis, and Neerhout), the Division of Hematology and Medical Oncology, Department of Medicine (Dr Segal), and the Department of Pathology (Dr Braziel), the Doernbecher Memorial Hospital for Children, and the Crippled Children's Division (Mr Allen), Oregon Health Sciences University, Portland, Ore.

Am J Dis Child. 1990;144(10):1117-1119. doi:10.1001/archpedi.1990.02150340063024

• TWo infants with congenital nonlymphoblastic leukemia were discovered to have mosaicism for trisomy 21. Both infants achieved durable spontaneous remissions. Trisomy was apparently restricted to the leukemic clone and could be detected in neither phytohemagglutinin-stimulated peripheral blood cells or bone marrow in either patient nor in myeloid progenitor cells from the second patient after resolution of the transient myeloproliferative disorder. We conclude that spontaneous remission of congenital leukemia is not confined to infants with partial or complete systemic trisomy 21 but can occur in genetically normal new-borns whose leukemic cells contain a third chromosome 21.

(AJDC. 1990;144:1117-1119)