November 1990

Blue Sclerae and Iron Deficiency

Author Affiliations

Department of Pediatrics St Louis University School of Medicine St Louis, MO 63104

Am J Dis Child. 1990;144(11):1180-1181. doi:10.1001/archpedi.1990.02150350010006

Sir.—Osler1 described the association of blue sclerae and iron deficiency anemia in teenaged girls. That finding received apparent further support from Kalra et al2 in a study of adult inpatients. We sought to validate this association in infants and young children. Thirty-four patients, ages 4 months to 5 years, 25 of whom were black and nine white, were examined by a pediatric house officer and attending physician. Anemia was defined as a hemoglobin value less than 105 g/L in children less than 2 years of age and less than 115 g/L in those over 2 years of age. The diagnosis of iron deficiency was confirmed by a free erythrocyte protoporphyrin value greater than 350 g/L of whole blood. Five of the 34 study patients had blue sclerae and only two of these five were anemic. Thus three patients with blue sclerae had no laboratory evidence of

First Page Preview View Large
First page PDF preview
First page PDF preview