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In Reply.—Dr Zuerlein correctly points out that heparin solution may dilute blood gas samples and lead to decreased Pco2 values. In our study, however, the heparinized 1-mL syringes contained 50 U of lyophilized heparin (Aspirator syringes, Marquest Medical Products, Englewood, Colo); thus, no dilutional effect would have occurred.
Although we are unaware of any effect of lyophilized heparin on blood gas values, any such effect would have been uniform in our study because prepackaged syringes were used. Thus, such an effect would not be a factor in the scatter demonstrated in our results.
COURTNEY SE, WEBER KR. Heparin's Effect on Blood Gas Analysis-Reply. Am J Dis Child. 1990;144(12):1288. doi:10.1001/archpedi.1990.02150360010006