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Article
January 1991

Picture of the Month

Author Affiliations

From the Division of Neonatology, Department of Pediatrics, University of Cincinnati, Ohio.

Am J Dis Child. 1991;145(1):113-114. doi:10.1001/archpedi.1991.02160010119030
Abstract

Denouement and Discussion 

Lowe's Syndrome  Lowe's syndrome, or oculocerebrorenal syndrome, is an X-linked hereditary disease characterized by congenital ocular disease, renal tubular dysfunction, hypotonia, moderate to severe bone disease, and mental retardation. It is present in all races, with a predominance in those with Caucasian and Asian ancestries.The disease has three identifiable stages. The first, during the newborn period, is characterized by ocular pathologic features. Nearly all affected individuals have congenital, ocular disease, renal tubular dysfunction, hypotonia, moderate to severe bone disease, and mental retardation. It is present in all races, with a predominance in those with Caucasian and Asian ancestries.

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