April 1991

Antibody Response to MMR Vaccination in Children Who Received IVIG as Neonates

Author Affiliations

Division of Neonatology Ahmanson Department of Pediatrics Cedars-Sinai Medical Center Los Angeles, CA 90048
Specialty Laboratories Inc Santa Monica, CA 90404
Division of Immunology Department of Pediatrics UCLA School of Medicine Los Angeles, CA 90024

Am J Dis Child. 1991;145(4):425-426. doi:10.1001/archpedi.1991.02160040081007

Sir.—The administration of intravenous immunoglobulin (IVIG) to

neonates has few or no acute short-term effects,1 but less is known about the subsequent effect on humoral immune function. We studied the response to measles, mumps, rubella (MMR) vaccination in five children who received multiple infusions of IVIG during the neonatal period.

We obtained serum from five children who had participated in a study of IVIG pharmakokinetics in infants of 32 weeks' gestation or less weighing 1500 g or less in the Cedars-Sinai Neonatal Intensive Care Unit, Los Angeles, Calif.2 The Table shows the gestational age and birth weight of each infant, the number of IVIG infusions, and total IVIG dose. These infants were subsequently vaccinated against rubeola, mumps, and rubella at 15 months of age. Serum samples were obtained 2 months after vaccination. The Table also shows the IgG response to MMR vaccination with reference ranges. Following

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