June 1991

Penile Vasculitis With Impending Necrosis Treated With Prostaglandin E1 Infusion

Author Affiliations

UCLA Medical Center Los Angeles, CA 90024

Am J Dis Child. 1991;145(6):604. doi:10.1001/archpedi.1991.02160060020012

Sir.—Prostaglandin E1 (PGE1) infusions have been used in the treatment of occlusive vascular diseases since 1973, when Carlson and Eriksson1 described subjective improvement in three of four patients with peripheral atherosclerotic vascular disease and ischemic rest pain given PGE1 by femoral artery infusion. Since that time, PGE1 has been reported to be effective in Raynaud's syndrome, peripheral vascular occlusive disease, and Kawasaki's disease.2-4 We report the dramatic clinical reversal of severe, apparently immune complex-mediated vasculitis of the penis following the use of intravenous PGE1 in an 8-year-old boy.

Patient Report.—An 8-year-old black boy presented to the UCLA Medical Center in 1981 with a 1-day history of severe pain and swelling of his penile shaft. He had no other somatic complaints, gave no history of recent febrile illness, and was able to void without difficulty on admission.

The patient had a complex

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