• Hemophiliacs infected with human immunodeficiency virus with a history of hypersensitivity reaction to a combination product of trimethoprim and sulfamethoxazole were desensitized orally. Six of the seven patients included in the study successfully completed the desensitization protocol and received trimethoprim-sulfamethoxazole for 5 to 7 months after desensitization (mean length of treatment, 5.7 months) for prophylaxis of Pneumocystis carinii pneumonia. The small number of patients and the short follow-up allow us to suggest that oral desensitization may be an effective and inexpensive means to treat hemophiliacs infected with human immunodeficiency virus with trimethoprim-sulfamethoxazole as prophylaxis against Pneumocystis carinii pneumonia.
Kletzel M, Beck S, Elser J, Shock N, Burks W. Trimethoprim-Sulfamethoxazole Oral Desensitization in Hemophiliacs Infected With Human Immunodeficiency Virus With a History of Hypersensitivity Reactions. Am J Dis Child. 1991;145(12):1428-1429. doi:10.1001/archpedi.1991.02160120096026