December 1991

Trimethoprim-Sulfamethoxazole Oral Desensitization in Hemophiliacs Infected With Human Immunodeficiency Virus With a History of Hypersensitivity Reactions

Author Affiliations

From the Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock. Dr Kletzel is now with the Department of Pediatrics, Children's Memorial Hospital, Chicago, Ill.

Am J Dis Child. 1991;145(12):1428-1429. doi:10.1001/archpedi.1991.02160120096026

• Hemophiliacs infected with human immunodeficiency virus with a history of hypersensitivity reaction to a combination product of trimethoprim and sulfamethoxazole were desensitized orally. Six of the seven patients included in the study successfully completed the desensitization protocol and received trimethoprim-sulfamethoxazole for 5 to 7 months after desensitization (mean length of treatment, 5.7 months) for prophylaxis of Pneumocystis carinii pneumonia. The small number of patients and the short follow-up allow us to suggest that oral desensitization may be an effective and inexpensive means to treat hemophiliacs infected with human immunodeficiency virus with trimethoprim-sulfamethoxazole as prophylaxis against Pneumocystis carinii pneumonia.

(AJDC. 1991;145:1428-1429)