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August 1992

Congenital Hypocalcemia: Transient or Persistent?-Reply

Author Affiliations

Division of Endrocrinology The Hospital for Sick Children 555 University Ave Toronto, Ontario, Canada M5G 1X8

Am J Dis Child. 1992;146(8):894. doi:10.1001/archpedi.1992.02160200016005

In Reply.—We thank Drs Liel and Harman-Baham for their comments regarding our article.1 They draw attention to an editorial correspondence describing a child with Dubowitz syndrome associated with transient congenital hypoparathyroidism and subsequent overt hypoparathyroidism.2 The course of that patient's disease is similar to the course we have observed in patients with partial hypoparathyroidism: transient neonatal hypocalcemia in the normal-weight newborn, a period of normocalcemia, development of mild hypocalcemia later in childhood, and an inappropriately low, but detectable, level of serum parathyroid hormone. This condition is probably more common than is recognized. We agree with Drs Liel and Harman-Baham that the true incidence of this disorder will be known only if serum calcium levels are measured regularly during childhood in all patients with transient congenital hypoparathyroidism.

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