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September 1992

Influenza Vaccination and Acute Otitis Media in Children-Reply

Author Affiliations

Department of Pediatrics Turku University Hospital SF-20520 Turku, Finland

Am J Dis Child. 1992;146(9):1019. doi:10.1001/archpedi.1992.02160210021008

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—Weller and Mann think that we have understood the reduction from 67% to 60% to represent an 83% decrease in incidence and to be statistically significant. Not even physicians make such kinds of statistical errors! By the "... incidence of AOM associated with influenza A... " we simply mean the number of cases of AOM that were clearly related to influenza A infection in the groups; the expression does not indicate the proportion of cases complicated by AOM among the children who developed influenza A. Therefore, we have correctly and deliberately used the complete sample population in the calculations (three [1.6%] of 187 in the vaccinated group vs 18 [9.6%] of 187 in the control group), resulting in an 83% decrease in incidence (P<.001).

The findings that the protective efficacy of the vaccination against influenza A was 83% and the incidence of AOM associated with influenza A was decreased by a

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