May 1994

Magnesium Deficiency as a Cause of Hypocalcemia in the CHARGE Association

Author Affiliations

From the Department of Pediatrics, Children's Medical Center of Brooklyn (NY).

Arch Pediatr Adolesc Med. 1994;148(5):486-489. doi:10.1001/archpedi.1994.02170050044008

Objective:  To discover the mechanism of hypocalcemia in a patient with the CHARGE (coloboma, heart disease, atresia choanae, retarded growth and development, genital hypoplasia, and ear anomalies) association.

Research Design:  Chemical and metabolic studies of serum, urine, stool, and muscle specimens.

Setting:  A university hospital affiliated with a municipal hospital.

Participant:  One patient with the CHARGE association and refractory hypocalcemia.

Measurements and Results:  Serum calcium level was 0.91 mmol/L (reference range, 2.20 to 2.58 mmol/L and serum magnesium level was 0.34 mmol/L (reference range, 0.80 to 1.20 mmol/L) prior to any therapy. After parenteral calcium and magnesium therapy, hypocalcemia persisted (1.46 mmol/L), while the serum magnesium level was 0.84 mmol/L. A needle biopsy of skeletal muscle tissue for the magnesium content confirmed a total magnesium deficiency despite normomagnesemia (muscle magnesium content, 517 μg/g [reference range, 800 to 1100 μg/g]). Magnesium deficiency was secondary to secretion of magnesium into the gastrointestinal tract (with a daily magnesium intake of 190 mg, a 24-hour nondiarrheal fecal excretion of magnesium was 2019 mg/kg [reference range, <1000 mg/kg of stool weight]).

Interventions:  Hypocalcemia was corrected only after 7 weeks of continual parenteral magnesium supplements to replenish the tissue magnesium deficiency.

Conclusions:  Patients with the CHARGE association often have hypocalcemia. Magnesium deficiency (with or without hypomagnesemia) is a cause of the hypocalcemia in at least one patient and may prove of significance in others.(Arch Pediatr Adolesc Med. 1994;148:486-489)