October 1994

Pathological Case of the Month

Author Affiliations

From the Departments of Pediatrics (Drs Laufer, Augarten, and Szeinberg) and Pathology (Dr Engelberg), The Chaim Sheba Medical Center, Tel Hashomer, Israel, affiliated with Sackler School of Medicine, Tel Aviv University.

Arch Pediatr Adolesc Med. 1994;148(10):1067-1068. doi:10.1001/archpedi.1994.02170100065013

This 11-year-old girl presented with enormous, painless enlargement of her left breast (Figure 1). Some increase in size relative to the right breast was noticed 5 months before her admission; however, explosive growth occurred during the last month. The results of her physical examination, except for a huge, smooth mass in her left breast, were normal. The skin was stretched and shiny, with distended veins over the tumor (Figure 2). There was no nipple discharge or associated axillary lymphadenopathy. Her pubertal development was of Tanner stage III. Simple resection removed a well-encapsulated tumor, 3× 20× 20 cm, weighing 1200 g (Figure 3 and Figure 4). The estrogen receptor content was low (6 fmol/mg protein) and there were no receptors for progesterone.

Diagnosis and Discussion 

Cystosarcoma Phylloides in an Adolescent Female  Cystosarcoma phylloides is an uncommon neoplasm of the breast composed of breast ducts and overgrowth of stroma and

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