February 1995

Antichlamydial Antimicrobial Therapy for Asthma-Reply

Author Affiliations

Divisions of Pulmonology and Infectious Diseases Department of Pediatrics State University of New York Health Science Center at Brooklyn Brooklyn, NY 11203-2098

Arch Pediatr Adolesc Med. 1995;149(2):220-221. doi:10.1001/archpedi.1995.02170140101024

We appreciate Hahn's taking the time to read and comment on our recent published study in the Archives1; however, we must take exception with some of those comments. Hahn states that we found evidence of C pneumoniae infection in 21 children with reactive airway disease, including nine children who had negative cultures but had "diagnostic" antibody. Unfortunately, diagnostic antibody was also present in 37.5% of the asymptomatic controls with negative cultures, which makes the significance of this antibody questionable. We have found that antibody to C pneumoniae, as determined by the microimmunofluorescence test, is frequently not predictive of who is actually infected as determined by culture and/or polymerase chain reaction.2 There are several possible reasons for this. Unlike Chlamydia trachomatis, the major outer membrane protein does not appear to be immunodominant in C pneumoniae infection. The major outer membrane protein appears to be the primary antigen presented

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