Since 1985, more than 400 new cases of childhood lead poisoning were diagnosed in Paris, France. The resurgence of lead poisoning is a major public health concern.1,2 The treatment of these children with increased blood lead levels was consistent with the guidelines of the Centers for Disease Control and Prevention (CDC), Atlanta, Ga,2-4 which recommend a lead mobilization test for patients with intermediate lead intoxication to determine which children would benefit from chelation therapy.
However, performing 24-hour provocative tests in young children has proved difficult: urine collection is often incomplete, and hospitalization is often necessary. The aim of our study was to decrease the urinary collection period of provocative tests to 5 hours and to assess the validity of this shortened procedure.
Patients and Methods. During a 17-month period between May 1989 and October 1990, 34 edetate calcium disodium (CaNa2 EDTA) mobilization tests were attempted in 32
Iniguez JL, Leverger G, Dollfus C, Gouraud F, Gamier R, Beauvais P. Lead Mobilization Test in Children With Lead Poisoning: Validation of a 5-Hour Edetate Calcium Disodium Provocation Test. Arch Pediatr Adolesc Med. 1995;149(3):338-340. doi:10.1001/archpedi.1995.02170150118024