We thank Dr Desch for educating us on the association of a white forelock with tuberous sclerosis. McWilliam and Stephenson1 describe 4 infants with at least 1 tuft of depigmented hair who eventually received a diagnosis of tuberous sclerosis. Although the site of the depigmented hair was indicated in only 2 of the infants and it was not a forelock in either of them, the possibility remains that an infant with tuberous sclerosis might have a white forelock. Dr Desch's case is an example. Patches of gray or white hair in infants, no matter where on the scalp, should, then, attract our attention to the possibility of this diagnosis.
Tunnessen WW, Simon NP, Simon MW. White Forelock Could Be Early Sign of Tuberous Sclerosis-Reply. Arch Pediatr Adolesc Med. 1996;150(6):651-652. doi:10.1001/archpedi.1996.02170310085021