A 5-DAY-OLD white male infant was admitted to the hospital because of progressive cyanosis and coolness of one leg. He had a history of emesis and loose stools, but no fever, trauma, or abnormal birth history. Because of vomiting, the formula had been changed from a low-protein to a soy-protein formula prior to admission to the hospital.
Physical examination revealed hepatosplenomegaly and a cool, cyanotic right leg. During exploratory surgery, a thrombosis of the right common femoral artery was removed. A white blood cell count was 21.8×109/L, hematocrit 59.8, and platelet count 42×109/L. The child had disseminated intravascular coagulopathy, as noted by a prothrombin time of 33.1 seconds, partial thromboplastin time of more than 300 seconds, fibrinogen level of less than 0.1 g/L, and positive test results for fibrin degradation products.
Despite successful removal of the thrombus, disseminated intravascular coagulopathy continued that required fresh frozen plasma
Long WW, Pawel B, Morrow G. Pathological Case of the Month. Arch Pediatr Adolesc Med. 1997;151(11):1165-1166. doi:10.1001/archpedi.1997.02170480095017