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In recent years whole human blood given by intramuscular injection has been used extensively for prophylaxis and treatment. Accidents have occasionally followed such injections. Thus, pyogenic infections have developed at the sites of injection, syphilis and malaria have been transmitted and allergic phenomena, such as urticaria, have been noted. The etiology of such occurrences is usually obvious. In this communication there is reported the study of a group of children in whom a definite reaction appeared after the intramuscular injection of whole blood, the reaction having an almost identical course in all the children in whom it developed. Approximately six days after the injection, the affected children suddenly became acutely ill, with fever and malaise, and the sites of injection became swollen, hot, red and painful. These symptoms lasted for three or four days and then subsided completely. A single reference in the literature to a similar reaction has been
RAPOPORT M, STOKES J. REACTION FOLLOWING THE INTRAMUSCULAR INJECTION OF WHOLE BLOOD. Am J Dis Child. 1937;53(2):471-480. doi:10.1001/archpedi.1937.04140090044004