This schematic depicts a disposable e-cigarette. Electronic cigarettes with refillable or replaceable cartridges typically have the cartridge on the end of the e-cigarette with the heating vapor coil. LED indicates light-emitting diode. Adapted from Wollscheid and Kremzner.3
Collaco JM, Drummond MB, McGrath-Morrow SA. Electronic Cigarette Use and Exposure in the Pediatric Population. JAMA Pediatr. 2015;169(2):177-182. doi:10.1001/jamapediatrics.2014.2898
Electronic cigarette (e-cigarette) use has gained recent widespread popularity and acceptance in the general population. What effect e-cigarettes may have on pediatric health remains unknown. Although many jurisdictions have laws that prevent the sale of e-cigarettes to minors and the use of e-cigarettes in public places, infants, children, and adolescents are increasingly exposed to them. In this pediatric-focused review, we discuss the history of these devices, user demographics, known health effects, and current legislative efforts to protect minors from exposure.
Electronic cigarettes (e-cigarettes) are designed to deliver vaporized nicotine for absorption through the respiratory tract through noncombustible means. The current incarnation of the e-cigarette was developed in China in 2003 and introduced in China in 2004, Europe in 2006, and the United States in 2007. Conventional cigarette manufacturer Philip Morris conducted research with e-cigarettes as early as the 1990s.1,2 The basic components of an e-cigarette include a cartridge containing a nicotine solution, a heating element that vaporizes the solution, and a power source for the heating element, which is frequently a rechargeable lithium battery (Figure). Activation of the e-cigarette through inspiration by the user or manual activation with a button triggers the delivery of a vaporized nicotine solution that can be inhaled (termed vaping).
Some e-cigarettes are single-use devices, whereas others have replaceable or refillable cartridges. In addition, larger commercially available devices known as tanks can operate with higher voltages and can release carcinogens, such as formaldehyde, in levels similar to those of conventional tobacco smoke.4 In addition to commercially available devices, some e-cigarette users build or modify their own devices, known as personal vaporizers or mechanical mods. The lack of uniformity among devices can lead to differences in vapor particle size and deposition in the respiratory tract, even when the same nicotine solution is used.5 This lack of uniformity in turn can provide a different user experience in terms of vapor production, systemic absorption of nicotine and nicotine solution components, and “throat hit,”6 that is, the sensation a user experiences in the oropharynx and lungs during inhalation of vapor.
The nicotine solutions for e-cigarettes are commercially available in several different concentrations of nicotine, ranging from 0% to 3.6%. However, studies have shown discrepancies in the actual content of nicotine vs the reported content, with variation ranging from 1% to 31% for different batches of the same brand of e-cigarettes.7,8 In addition, variable systemic absorption of nicotine can occur, even with similar concentrations of nicotine solutions, with naive users absorbing less nicotine compared with experienced users owing to different patterns of inhalation.9 The e-cigarette solutions may also contain flavorings, such as traditional tobacco blends, menthol, and nontraditional flavorings (eg, bubble gum, cocktail, and candy flavors). Whether these additives have the potential to produce toxic byproducts during vaping has not been determined. In addition, electronic nicotine delivery systems have been used for vaping nonnicotine substances,10 including the active ingredients in marijuana. Because of the lack of regulations governing manufacturing and sales of these devices and the variability among electronic nicotine delivery systems, their components, and their solutions,11 the health risks associated with e-cigarette use and bystander exposure are not understood completely.
Among adolescents and adults, the rates of awareness and first use of e-cigarettes have doubled from 2008 through 2012.12 From 2011 through 2012 among middle school students in the United States, e-cigarette use (ever) increased from 1.4% to 2.7%, and current use (defined as any use within the past 30 days) increased from 0.6% to 1.1%. For high school students, ever use increased from 4.7% to 10.0%, and current use increased from 1.5% to 2.8% (P < .05 for all).13 As of 2011, awareness among US adults was 57.9%, with 6.2% of adults reporting ever having used them.14 The prevalence of trying e-cigarettes is higher among smokers of conventional cigarettes compared with former smokers and those who never smoked.12,14 The International Tobacco Four-Country Survey (the United States, the United Kingdom, Canada, and Australia)1 found that awareness of e-cigarettes was associated with being a heavy smoker (>1 pack a day), white, male, and young (18-24 years); with having a moderate educational level; and with having a moderate to high income. On the other hand, trying an e-cigarette was associated with being a nondaily smoker, female, and young; with having a high income level; and with perceiving reduced harm compared with conventional cigarettes. In the same survey, current use was associated with being a smoker and having a high educational level.
Adolescent characteristics associated with ever using e-cigarettes have also been reported to be different from those of adults. The proportion of adults who have never smoked but who have tried e-cigarettes was reportedly lower than the same proportion of adolescents.15 A recent survey of more than 15 000 US adolescents in grades 6 through 12 found that e-cigarette use was significantly lower in girls and in African American and Hispanic youth and higher for those who smoked conventional cigarettes or who had friends who smoked.16 Among older adolescent children of alcoholic fathers, Lessard and colleagues17 reported that e-cigarette use was associated with current use of cigarettes, alcohol, and marijuana. In another study,18 adolescent users of e-cigarettes were found to be just as likely as tobacco users to report the use of alcohol, cigars, smokeless tobacco, and marijuana but were more likely to report the use of blunt wraps and hookahs. Common locations for adolescent use of e-cigarettes based on focus group data from male high school students in the US Southwest include everywhere (38%), school bathrooms (26%), home (21%), school staircases (11%), and school cafeterias (4%).19
Although 76.3% of adolescent e-cigarette users also smoke conventional cigarettes,13,20 recent analyses of data from the National Youth Tobacco survey21 (adolescents in grades 6-12) revealed that the use of e-cigarettes increased from 79 000 to more than 263 000 (0.9% of the nonsmoking youth population who use e-cigarettes) from 2011 through 2013 among US youths who have never smoked cigarettes. This 3-fold increase in e-cigarette use among adolescents who have never smoked suggests increased acceptance of e-cigarettes in this population. Whether widespread e-cigarette acceptance in the adolescent population will increase addiction to nicotine is unknown.
Few studies have examined the short- and long-term health effects of e-cigarettes on primary users. One study22 reported higher levels of exhaled nitric oxide in e-cigarette users, suggesting that e-cigarettes can cause airway inflammation. Other studies in adults23,24 have found minimal acute cardiovascular and pulmonary effects in adult e-cigarettes users. Although nicotine exposure by itself does not cause tumors, it has been shown to promote tumor growth and metastasis.25 Therefore, whether the long-term use of e-cigarettes can increase the risk for malignant disease in people with a predisposition for tumor development is unknown. Addiction to nicotine is also a potential concern for e-cigarette users because of the high nicotine content in many e-cigarette solutions. A study in adolescents who smoke conventional cigarettes found that certain subgroups of smokers were more likely to become addicted to nicotine.26 Nicotine dependence occurs in several stages, beginning with experimentation and leading to long-term use, abuse, and dependence in susceptible individuals.27 Symptoms in experimental or nondaily smokers that predicted an increased likelihood of becoming daily smokers at 48 months included the need to smoke in the morning, choosing to spend money on smoking instead of lunch, smoking when ill, and smoking when it was forbidden. Whether these same subgroups of adolescents will be at risk for nicotine addiction when trying or using e-cigarettes remains unclear.
Although some manufacturers of e-cigarette liquids describe their products as being made from US Pharmacopeial Convention– or food-grade ingredients, the inhalational properties of the chemical compounds have not been assessed. The carrier agents and flavorings may also have health effects independent of those of nicotine. Known and suspected carcinogens, such as formaldehyde, acetaldehyde, and acrolein, are generated when carrier agents, such as propylene glycol or vegetable glycerin, are heated to high temperatures.28 Although the primary components of vaporization for e-cigarettes are nicotine and its carrier agent, e-cigarette solutions may contain flavoring agents and other chemicals, some of which are known carcinogens. Chromatographic and spectroscopic analysis of 12 brands of e-cigarettes detected the presence of several groups of known toxins and/or carcinogens, including carbonyls, volatile organic compounds, nitrosamines, and heavy metals, albeit in levels lower than those found in conventional cigarette smoke.28
There are limited data about the health effects on a bystander exposed to secondary e-cigarette vapor. In contrast to conventional cigarettes, secondary exposure to e-cigarette vapor does not involve exposure to combustion byproducts, and e-cigarettes reportedly generate minimal sidestream emissions.29 Although the exposure to the exhalant vapors of e-cigarettes may be less harmful than exposure to those of conventional cigarettes, recent studies suggest that e-cigarette vapor may not be entirely harmless. Schober and colleagues22 reported an increase in the concentration of particle numbers, 1,2-propanediol, glycerin, and nicotine in indoor air during sessions of e-cigarette use. Previously, Schripp and colleagues30 also found increased levels of 1,2-propanediol, diacetin, and nicotine by gas chromatography from 1 exhaled e-cigarette puff delivered by a user. Indoor nicotine levels and particle concentrations generated by e-cigarette users have been shown to be higher than background levels but lower than levels generated by conventional cigarette smoking.29,31 Nevertheless, Flouris and colleagues24 reported similar levels of serum cotinine in adults passively exposed to e-cigarettes compared with adults exposed to secondary tobacco smoke. Ballbè and colleagues32 also reported similar salivary and urine cotinine levels in nonsmokers who were exposed to e-cigarette emissions or conventional cigarettes. Another study documented higher particulate levels with e-cigarettes containing nicotine-free solutions compared with those containing nicotine,31 suggesting that the use of e-cigarettes with flavored non–nicotine-containing solutions may still pose a risk to bystanders. The potential for tertiary (or thirdhand) exposure from e-cigarettes has been demonstrated recently by Goniewicz and Lee,33 who reported measurable nicotine levels in samples from hard surfaces exposed to e-cigarette emissions. In summary, the currently available data suggest that indirect exposure to e-cigarette vapor may result in exposure of nonusers to toxic compounds through secondary and tertiary exposure.
For now, no data are available concerning the effects of maternal e-cigarette use on the developing fetus or neonate. In animal studies,34 exposure to nicotine during fetal development has been associated with lung abnormalities. Children exposed to maternal smoking have been reported to have a higher incidence of wheezing in early life.35,36 Other studies in rodents34,37,38 have demonstrated that nicotine exposure in utero and during neonatal life can inhibit alveolar growth and cause histologic changes similar to those caused by emphysema. Disruption of lung vascularization due to fetal and neonatal nicotine exposure has also been reported in a rodent model.39
Behavioral abnormalities have been reported in the offspring of mothers who smoked during pregnancy.34 The development of attention-deficit/hyperactivity disorder in children has been shown to be associated with maternal smoking during pregnancy, whereas rodent models have demonstrated increased hyperactivity in offspring with prenatal exposure to nicotine.40 In neonatal rats, Huang and colleagues41 reported hippocampal changes with chronic neonatal nicotine exposure, possibly accounting for cognitive changes caused by nicotine exposure. The effect of in utero and postnatal exposure to e-cigarette emissions on the health of neonates and infants remains unknown. However, infants can absorb nicotine through multiple exposure routes, including inhalation, skin absorption, oral ingestion, and breast milk.42,43 Higher urine levels of cotinine (>10-fold) have been reported in breastfed infants of mothers who smoked more than 5 cigarettes a day compared with bottle-fed infants of mothers who smoked.44 Because rapid brain and lung development takes place during early life, exposure to nicotine through e-cigarette emissions may cause adverse health concerns in this particularly vulnerable age group.
Unintentional exposure to nicotine-containing e-cigarette solutions is also an emerging health hazard. The Centers for Disease Control and Prevention reported that calls per month related to e-cigarette exposure had dramatically increased from 1 in September 2010 to 215 in February 2014.45 These calls by February 2014 accounted for 41.7% of the combined monthly calls related to cigarettes and e-cigarettes. Exposure to e-cigarettes affected primarily individuals younger than 5 years (51.1%) and older than 20 years (42.0%). Commonly reported exposures included ingestion of solutions (68.9%), inhalation (16.8%), eye exposure (8.5%), and dermal exposure (5.9%). In addition, an adverse health effect was reported in 57.8% of the calls for which severity information was recorded; commonly reported effects included emesis, nausea, and eye irritation. Many of these exposures may be preventable if child-proof containers were in use, but such containers are not currently required by federal law. One suicide via intravenous injection of a nicotine solution was also reported by the Centers for Disease Control and Prevention.45 Finally, reported incidents of lithium battery explosions with recharging, leading to fires and burns, have been acknowledged by the industry.46 More studies in children are needed to determine the effect of e-cigarette exposure on childhood health, including the risk for and consequences of accidental nicotine exposures from e-cigarette solutions.47
Many adult users of conventional cigarettes believe e-cigarettes to be less harmful than conventional cigarettes, but this percentage is decreasing with time from 84.7% in 2010 to 65.0% in 2012.48 A national survey of 24 000 youth in grades 6 through 12 found that 30.6% believed that e-cigarettes were less harmful than conventional cigarettes, and 18.6% believed that they were equally or more harmful, with the remaining 50.8% reporting that they had not heard of or did not know enough about e-cigarettes.49 Focus groups of male high school students suggested that common reasons for adolescent use of e-cigarettes included concealment (40%), social approval (26%), harm reduction compared with conventional cigarettes (19%), and lack of odor compared with conventional cigarettes (15%).19
Unfortunately, available data suggest that clinicians may not be informed adequately regarding the use of e-cigarettes and their potential effects on health. A 2013 survey of clinicians who treated adolescents in Minnesota50 stated that 92% of respondents were aware of e-cigarettes, but most (83.1%) described knowing nothing to a little about e-cigarettes, and only 24% had heard of e-cigarettes through professional sources. Although little research has been published on the short- and long-term safety of e-cigarettes, most clinicians in that study agreed that e-cigarettes were safer than conventional cigarettes (65.5%). Those who believed that e-cigarettes were safer were less likely to believe that discussing their use with patients or their parents was important. In terms of potential prenatal counseling, a 2012 survey of members of the American College of Obstetricians and Gynecologists51 reported that only 5% of respondents described themselves as fully informed about e-cigarettes. Of those surveyed, 29.0% reported that e-cigarettes were safer than conventional cigarettes, and 13.5% believed that they had no health effects at all. From the observation that people usually smoke before progressing to the use of illicit drugs, recent animal studies52,53 have demonstrated that nicotine can augment the potential for cocaine addiction by increasing activation of nicotinic acetylcholine receptors in the amygdala. Whether the use of nicotine-containing e-cigarettes by adolescents who have never smoked will increase the prevalence of illicit drug use in this population is unknown.
In the late 2000s, multiple small businesses launched the sales and marketing of e-cigarettes,54 with most of these small businesses focusing on a single e-cigarette and/or product. However, with the growing popularity of e-cigarettes, all of the major international corporations that sell conventional cigarettes have purchased e-cigarette brands or introduced their own brands, including Green Smoke and MarkTen (Phillip Morris/Altria), Vuse (Reynolds American/Lorillard), Vype (British American Tobacco), Puritane (Imperial Tobacco), and Blu (Lorillard sale pending to Imperial Tobacco). With the entry of these corporations into the marketplace, 10 companies are estimated to hold more than 70% of the US market share.54 Bloomberg Industries55 estimates that global sales were $3.5 billion in 2013 and expected to rise to $7.5 billion in 2015. A Bloomberg Industries projection54 suggests that sales of e-cigarettes could exceed those of conventional cigarettes by as early as 2023. In addition, e-cigarettes are becoming more readily available as the percentage of tobacco-selling retailers also selling e-cigarettes increased from 24.7% to 59.9% from 2012 to 2013 in a study conducted in Virginia and North Carolina.56 In contrast to conventional cigarettes, which are taxed at the federal and state levels (and within some local jurisdictions) throughout the United States, government taxation on e-cigarettes is limited to state taxes only in Minnesota and North Carolina.57
Despite the potential health risks to children posed by e-cigarette use and nicotine addiction, advertisements for e-cigarettes can be seen readily by minors in the United States. Exposure to e-cigarette advertisements on television (primarily cable) has been estimated to have increased by 256% from 2011 through 2013 for youth aged 12 to 17 years.58 As much as 8.0% of the online audience for e-cigarette advertisements is estimated to be younger than 18 years, and some advertisement occurs on websites, where as many as 35% of the audience may be younger than 18 years.59 No federal restrictions on e-cigarette advertising currently exist in the United States. More problematic, however, is that some marketing of e-cigarettes has been targeted at children according to the US Food and Drug Administration (FDA),2,60 which specifically cites the fact that candy and fruit flavors are “especially attractive to children and young adults.”60(p23146) A 2014 US Congressional investigation stated that: “The findings of this investigation reveal that e-cigarette companies may indeed be taking advantage of the regulatory vacuum that currently exists to market their products to youth.”61(p2871)
Advertisements for e-cigarettes often indirectly reference smoking cessation to promote the purchase of e-cigarettes.59,62 A cross-sectional survey of more than 5000 smokers in the United Kingdom who had attempted to quit using conventional cigarettes found that those using e-cigarettes were more likely to report abstinence than those who used nicotine replacement therapies (adjusted odds ratio, 1.63 [95% CI, 1.17-2.27]) or no aid at all (adjusted odds ratio, 1.61 [95% CI, 1.19-2.18]).63 However, randomized clinical trials have not established an overwhelming benefit to recommend e-cigarettes as a superior method for cessation. A randomized clinical trial of 657 conventional cigarette users in New Zealand64 found no difference in abstinence rates between those randomized to e-cigarettes vs those randomized to nicotine transdermal patches. Another trial of 300 Italian users of conventional cigarettes65 found no difference in abstinence rates between those randomized to receive 1 of 2 nicotine-containing e-cigarettes vs those who received non–nicotine-containing e-cigarettes. A recent survey of more than 15 000 US adolescents in grades 6 through 1216 (of whom 3.2% of respondents reporting having used e-cigarettes) found that e-cigarette use was higher among conventional cigarette users (adjusted odds ratio, 58.44 [95% CI, 34.71-98.39]) but that e-cigarette use was not associated with a desire to quit using conventional cigarettes or with recent quit attempts. To our knowledge, no published studies have reported on the effectiveness of e-cigarettes as a means for cessation of conventional cigarette use in adolescents.
A July 2014 position statement from the Forum of International Respiratory Societies2 (which includes the American College of Chest Physicians and the American Thoracic Society) called for precautionary restrictions or bans on electronic nicotine delivery devices until more information on their safety is available. Although an August 2014 policy statement from the American Heart Association23(p421) stated that “[e]ven if there are some intrinsic adverse health effects of e-cigarettes, there would be public benefit if e-cigarettes proved to be much less hazardous than combustible cigarettes and if smokers could switch entirely from conventional cigarettes to e-cigarettes,” the American Heart Association supported FDA regulation of e-cigarettes covering marketing, youth access, quality control, and so on.
Although the sales of all e-cigarettes are prohibited in some countries (eg, Brazil and Mexico), sales of only nicotine-containing e-cigarettes are banned in others (eg, Australia and Canada), and sales to minors will be prohibited across the European Union by 2016, no federal regulations address marketing and sales to minors in the United States.23 In the absence of federal regulation, as of October 2014, 41 states have statutes prohibiting the sale of e-cigarettes to minors.66 Although many US municipalities have banned e-cigarette use in workplaces, only 3 states (New Jersey, North Dakota, and Utah) and the District of Columbia have banned workplace use statewide.
In April 2014, the FDA issued a proposed rule for comments on whether to regulate e-cigarettes and additional tobacco products, including cigars, pipe tobacco, certain dissolvables that are not “smokeless tobacco,” gels, and water pipe tobacco. The proposed regulations for e-cigarettes would ban sales to minors, require health warnings on packaging, require manufacturers to register with the FDA and report ingredients, and allow manufacturers to make health claims (such as being a cessation aid) only if the FDA confirms that the scientific evidence supports the claim.60 The proposed rules would not ban flavoring or advertisements. This proposal will be finalized after the FDA completes review of the public commentary.
Use of e-cigarettes has recently gained widespread popularity and acceptance in the general population, and the possible effect on pediatric health is unknown. Although many jurisdictions have laws that prevent sales of e-cigarettes to minors and use of e-cigarettes in public places, children and adolescents are increasingly exposed to e-cigarettes. Studies are needed to determine the effect of e-cigarette use and exposure on pediatric health in utero through adolescence. In the absence of data regarding risks to health, pediatricians and other clinicians should assess exposure to e-cigarettes as part of a history of secondary smoke exposure and be prepared to counsel on eliminating this exposure. In addition, given the potential risk for nicotine addiction, clinicians should be prepared to ask adolescents about e-cigarette use as part of a social assessment and to discuss the potential health risks associated with using e-cigarettes and vaporizers for other substances.
Accepted for Publication: October 19, 2014.
Corresponding Author: Sharon A. McGrath-Morrow, MD, MBA, Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, David M. Rubenstein Bldg, 200 N Wolfe St, Baltimore, MD 21287 (email@example.com).
Published Online: December 29, 2014. doi:10.1001/jamapediatrics.2014.2898.
Author Contributions: Dr Collaco and McGrath-Morrow had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: All authors.
Acquisition, analysis, or interpretation of data: Drummond.
Drafting of the manuscript: Collaco, McGrath-Morrow.
Critical revision of the manuscript for important intellectual content: All authors.
Administrative, technical, or material support: All authors.
Study supervision: McGrath-Morrow.
Conflict of Interest Disclosures: Drs Collaco and McGrath-Morrow have received funding from the American Academy of Pediatrics to study the health effects of e-cigarette exposure. No other disclosures were reported.