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Article
June 1968

Clinical Trial of Live Attenuated Rubella Virus Vaccine, HPV-77 Strain

Author Affiliations

New York
From the Department of Pediatrics, New York University School of Medicine, and the Willowbrook State School, Staten Island, NY.

Am J Dis Child. 1968;115(6):655-657. doi:10.1001/archpedi.1968.02100010657003
Abstract

IN 1966, Parkman, Meyer, and their colleagues described preliminary vaccine trials with a strain of rubella virus which had been attenuated by 77 passages in primary African green monkey kidney (AGMK) tissue culture.1,2 This strain, designated HPV-77, exhibited desirable qualities of immunogenicity and obvious attenuation in man. The present report describes our experience with HPV-77 virus in a series of vaccine trials which involved 48 children.

Materials and Methods  Vaccine.—The details of the preparation and safety testing of HPV-77 vaccine have been described by Meyer et al.1,2 The vaccine was supplied in single-dose vials which were stored at −65 C until use. Each vaccinated child received rubella vaccine (HPV-77), 0.5 ml subcutaneously. This dose represented 500 tissue culture interfering doses50 (TCID50), based on a titration in primary AGMK tissue culture using echovirus type 11 challenge.3Study Population and Experimental Design.—The 48 children were admitted

References
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Parkman, P.D., et al:  Attenuated Rubella Virus , New Eng J Med 275:569-574, 1966.Article
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Meyer, H.M., Jr.; Parkman, P.D.; and Panos, T.C.:  Attenuated Rubella Virus , New Eng J Med 275:575-580, 1966.Article
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Parkman, P.D.; Buescher, E.L.; and Artenstein, M.S.:  Recovery of Rubella Virus From Army Recruits , Proc Soc Exp Biol Med 111:225-230, 1962.Article
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Green, R.H., et al:  Studies of the Natural History and Prevention of Rubella , Amer J Dis Child 110:348-365 ( (Oct) ) 1965.Article
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Stewart, G.J., et al:  Rubella Virus Hemagglutination-inhibition Test , New Eng J Med 276: 554-557, 1967.Article
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Meyer, H.M., Jr., et al:  Clinical Studies With Experimental Live Rubella Virus Vaccine (Strain HPV-77) , Amer J Dis Child 15:648-654 ( (June) ) 1968.Article
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Lepow, M.L., et al:  A Trial With Live Attenuated Rubella Vaccine , Amer J Dis Child 15: 639-647 ( (June) ) 1968.
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Krugman, S., et al:  Studies on Immunity to Measles , J Pediat 66:471-488, 1965.Article
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