Liew and colleagues evaluated whether prenatal exposure to acetaminophen increases the risk for developing attention-deficit/hyperactivity disorder–like behavioral problems or hyperkinetic disorders (HKDs) in children. Cooper and colleagues provided a related Article .
Freedman et al determine whether increasing emergency department ondansetron use has resulted in a reduction in intravenous rehydration rates. Keren provides commentary in a related editorial.
Santos et al assessed the effectiveness of a peer-led healthy living program called Healthy Buddies on weight gain and its determinants when disseminated at the provincial level to elementary school students.
Llewellyn et al test the hypothesis that satiety responsiveness is an intermediate behavioral phenotype associated with genetic predisposition to obesity in children. From a twin cohort, they included 2258 unrelated children, one randomly selected from each twin pair, and assessed a polygenic risk score, adiposity, and satiety responsiveness.
Based on the UK Gemini population-based twin cohort, van Jaarsveld et al test the hypothesis that sibling differences in infant appetite predicted differential weight gain during childhood. Growth trajectories were analyzed from birth to age 15 months. Appetite during the first 3 months was assessed with the Baby Eating Behaviour Questionnaire.
Sulheim et al investigate the cause of chronic fatigue syndrome in adolescents and the effect of clonidine therapy.
Peterson et al estimate the proportion of US infants with late detection of critical congenital heart disease (CCHD) based on existing clinical practice and investigate factors associated with late detection. See the Editorial by Taylor and Phillipi.
Hobbs and coauthors report on the current state of the genetic epidemiology of birth defects and comment on future challenges and opportunities. They consider issues of study design and discuss common variant approaches, including candidate gene studies and genome-wide association studies. They also discuss the complexities embedded in exploring interactions between genes and the environment.