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Letters to the Editor
September 2005

Olanzapine and Olanzapine-Fluoxetine Combination Treatment and Bipolar I Depression

Arch Gen Psychiatry. 2005;62(9):1052. doi:10.1001/archpsyc.62.9.1052-a

We read with great interest the article by Tohen et al1 “Efficacy of Olanzapine and Olanzapine-Fluoxetine Combination in the Treatment of Bipolar I Depression.” We also attended a presentation at the 2003 American Psychiatric Association Annual Meeting2 when the same study was presented and notice rather strangely that the remission rates of the study on both occasions were different even though the study population was the same. At the American Psychiatric Association meeting, the remission rates quoted were placebo, 29.1%; olanzapine, 40.5%; and olanzapine-fluoxetine combination, 56.3%. On the other hand, in the November article, the rates quoted were placebo, 24.5%; olanzapine, 32.8%; and olanzapine-fluoxetine combination, 48.8%. Could the authors please explain the reason(s) for the disparities?

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