We agree that a mediating role of substance use disorders (SUD) in explaining
the association between major depressive disorder (MDD) and later ASPD warrants
examination. We have conducted additional analyses to test this hypothesis.
The original analyses of 551 youths examined simultaneous associations
between adolescent MDD, disruptive disorder (attention-deficit/hyperactivity
disorder, conduct disorder, or opposition-defiance disorder) and anxiety disorder
(overanxious disorder or social phobia) and young adult ASPD, controlling
for age, sex, socioeconomic status, childhood maltreatment, family status
(2 parents vs mother only), and parental conflict.1
Disorders, available from mother and youth responses to the Diagnostic Interview
Schedule for Children, met DSM-III-R criteria for diagnoses.
Kasen S. Mirtazapine in the Treatment of Panic Disorder. Arch Gen Psychiatry. 2002;59(7):666. doi: