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Letters to the Editor
July 2002

Mirtazapine in the Treatment of Panic Disorder

Arch Gen Psychiatry. 2002;59(7):666. doi:

In reply

We agree that a mediating role of substance use disorders (SUD) in explaining the association between major depressive disorder (MDD) and later ASPD warrants examination. We have conducted additional analyses to test this hypothesis.

The original analyses of 551 youths examined simultaneous associations between adolescent MDD, disruptive disorder (attention-deficit/hyperactivity disorder, conduct disorder, or opposition-defiance disorder) and anxiety disorder (overanxious disorder or social phobia) and young adult ASPD, controlling for age, sex, socioeconomic status, childhood maltreatment, family status (2 parents vs mother only), and parental conflict.1 Disorders, available from mother and youth responses to the Diagnostic Interview Schedule for Children, met DSM-III-R criteria for diagnoses.

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