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Commentary
June 1999

Miles to Go Before We Sleep

Arch Gen Psychiatry. 1999;56(6):556. doi:10-1001/pubs.Arch Gen Psychiatry-ISSN-0003-990x-56-6-ycm9067

SHOULD a reader of my article1 be tempted to conclude that genetics will soon solve psychiatry's most serious problems, the comments of Goldman2 and Kendler3 will serve to bring this dreamer back to earth. Both major contributors to psychiatric genetics, Goldman and Kendler have firsthand knowledge of the many challenges that lie ahead. They are right to remind us that the hunt for gene variants that influence susceptibility to mental illness is only a prelude to "a further agenda"2 and that we are just approaching the base camp of the "big mountain."3

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