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To the Editor Ross et al reported “no significant association between antidepressant medication exposure and spontaneous abortion (odds ratio [OR], 1.47; 95% CI, 0.99 to 2.17; P = .055)” (italics, our emphasis).1(p436) Confidence intervals provide inferential evidence about the range of plausible values for the population parameter of interest.2,3 A simple examination of the values covered by the reported 95% CI from 0.99 to 2.17 suffices to show that an association between the exposure to antidepressant medication and spontaneous abortion is likely and that results are nonnegligible from a clinical perspective. Results are not statistically significant but the differences are of clinical interest.
Tufanaru C, Jureidini J. Antidepressant Medication and Spontaneous Abortion“No Significant Association”? Clinically Significant Association!. JAMA Psychiatry. 2013;70(12):1373-1374. doi:10.1001/jamapsychiatry.2013.2274